Cut the bread into cubes about 1” square. Place the bread cubes in a large bowl. Sprinkle with salt, pepper, garlic powder, oregano and Parmesan cheese. Drizzle olive oil over bread.
Toss bread cubes until evenly coated with seasonings and oil. Place the seasoned bread cubes on a baking sheet in a single layer.
Cook for 25-30 minutes or until croutons are nicely golden brown. Remove and allow to cool slightly.