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Grilled Cheese Florentine

5 from 4 votes

This Grilled Cheese Florentine is a hearty vegetarian sandwich filled with tender baby spinach, juicy fresh tomatoes, thinly sliced red onion, and shredded mozzarella. And best of all, there’s no need to stand over the stove since this sandwich is baked in the oven. It’s a no-fuss dish that can serve as the main course or pair easily with your favorite sandwich sides.

Saturday lunches at our home are usually very casual, throw-together-whatever’s-in-the-fridge kinds of meals. More often than not, that means sandwiches. Sandwiches with lots of cold cuts and cheese.

Finished sandwich on a white serving plate.

But sometimes, I just want something different. Something quick and easy and out of the ordinary.

This sandwich perfectly fits that description. It’s different from our usual cold-cut laden fare and piled so high with good-for-you and good-tasting ingredients that you might not even realize that it’s vegetarian. It’s honestly one of the best grilled cheese sandwiches I’ve ever made.

And if you have eaters who want a sandwich with more protein, you could easily add a little sliced leftover rotisserie chicken. Yum.

Recipe Quick View

Cuisine: American
Cooking Method: Oven
Total Time: 23 Minutes

Servings: 2
Primary Ingredient(s): Baby Spinach, Mozzarella, Onion, Tomato, Whole Grain Bread
Skill Level: Easy

WHAT PEOPLE ARE SAYING …

“Excellent flavor! Will make this sandwich often. I put it in my panini press instead of the oven. Pairs wonderfully with creamy broccoli soup.”
— Sarah

Ingredient Notes

All ingredients you'll need to make this recipe.
Baby spinach, red onion, tomato, garlic, shredded mozzarella cheese, olive oil, salt, pepper, whole grain bread.

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  • Baby SpinachFresh baby spinach is the primary ingredient in this sandwich. I chose it because it’s very tender and soft. Plus, it wilts nicely when heated.
  • Red Onion — A little bit of thinly sliced red onion adds some crunch and a nice, mild flavor.
  • Tomato — A tomato brightens up the flavors with slight acidity. I prefer to use Roma (plum) or homegrown ripe tomatoes.
  • Garlic — Just one little clove of garlic adds loads of flavor. Be sure to mince or grate it finely.
  • Mozzarella Cheese — Mozzarella is known for its great “pull” when melted in a sandwich. You’ll need a low-moisture mozzarella, preferably in a block. I recommend grating it yourself for the best melt, but pre-shredded is okay. If you grate the cheese yourself, you’ll need 4 ounces to equal 1 cup.
  • Extra Virgin Olive Oil — I use a little drizzle of olive oil to help keep the filling moist.
  • Whole Grain Bread — Choose sturdy bread like whole wheat, sourdough, or rye. The bread needs to stand up to the moist filling while getting nice and toasty. Soft white bread, while delicious, isn’t a good choice for this recipe.

The complete ingredient list with detailed measurements is included in the printable recipe card at the bottom of this post.

How I Make Grilled Cheese Florentine Sandwich

  1. Preheat the oven to 425 F.
Filling ingredients in a mixing bowl.
STEP 2.
Filling ingredients tossed together in a bowl.
STEP 3.
  1. Combine the spinach, red onion, diced tomato, garlic, and mozzarella in a large bowl. Toss it all together until it’s well combined.
  2. Drizzle on the olive oil, add a little salt and pepper, and toss again.
Bread on a parchment lined baking sheet topped with sandwich filling.
STEP 4.
Second slice of bread added to each sandwich.
STEP 4.
  1. Now, spray a baking sheet with cooking spray (or use parchment paper) and line up your bread. Top two of the slices with half each of the mixture. Really pile it up high and don’t leave anything in the bowl! Top those with the other two slices of bread.
Browned sandwiches on a baking sheet.
STEP 5.
Finished sandwiches transferred to a white serving plate.
STEP 6.
  1. Place the baking sheet in the oven for 7 to 9 minutes or until the spinach has started wilting and the bread is golden brown. Flip the sandwiches over and cook for another 3 or 4 minutes or until the second piece of bread has toasted.
  2. Transfer each sandwich to a plate. Be sure to scoop up any of the filling that might have escaped while in the oven and put that alongside.
Finished sandwich on a white serving plate.

Possible Variations

  • Although I can’t advise on specific dietary needs, it is my understanding that this recipe is appropriate for vegetarians. If you’d like to add a boost of protein, you might add slices of rotisserie chicken or baked ham.
  • Try other cheeses that melt well, such as Monterey Jack, Gruyère, or sharp cheddar.
  • Swap out the spinach for kale or arugula for a different flavor.

Menu Suggestions

Cozy Comfort Lunch

Vegetarian Family Dinner

Quick and Easy Weeknight Meal

  • Main Course: Grilled Cheese Florentine
  • Side: Garlic Parmesan Roasted Broccoli
  • Dessert: Greek Yogurt with Honey and Mixed Nuts

Questions About Grilled Cheese Florentine Sandwich

Why is it called “Florentine?”

So, “Florentine” in recipes means dishes that contain spinach and references the city of Florence, Italy. When you see a recipe with the word Florentine in the title it just means that one of the main ingredients is spinach. That’s all!

What’s the best bread to use?

For this sandwich, I chose a hearty whole wheat bread. You’ll need something substantial like sourdough, rye, or pumpernickel. Soft breads such as white sandwich bread won’t quite stand up to the filling.

Can I use another type of cheese?

Of course. Select a cheese that melts easily and grate it yourself. The pre-grated cheeses are great for some applications, but they contain a starchy coating that doesn’t work well in this recipe. Monterey Jack or a sharp white Cheddar would be great as would any type of Swiss such as Gruyere. A tablespoon or two of grated Parmesan added to the filling would be nice. 

Can I make this sandwich on the stovetop?

You can cook it on the stovetop, but you’ll need to watch carefully. I would cook it on no more than medium heat in a heavy large skillet with a little butter or oil and flip it only once.

Lana Stuart.

Questions? I’m happy to help!

If you have more questions about the recipe, or if you’ve made it and would like to leave a comment, scroll down to leave your thoughts, questions, and/or rating!

Thanks so much for stopping by!

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Finished sandwich on a white serving plate.

Grilled Cheese Florentine

This Grilled Cheese Florentine is a hearty vegetarian sandwich filled with baby spinach, diced tomatoes, red onion, and shredded mozzarella.
5 from 4 votes
Print It Rate It
Course: Main Dishes
Cuisine: American
Prep Time: 10 minutes
Cook Time: 13 minutes
Total Time: 23 minutes
Servings: 2 servings
Calories: 235kcal
Author: Lana Stuart

Ingredients

  • 2 cups baby spinach packed, washed and dried
  • ¼ medium red onion sliced very thinly
  • 1 tomato diced (juices reserved)
  • 1 small garlic clove minced finely
  • 1 cup shredded mozzarella cheese (4 ounces before shredding)
  • 2 teaspoon extra virgin olive oil
  • Salt and black pepper to taste
  • 4 slices whole grain bread

Instructions

  • Preheat the oven to 425.
  • Combine the spinach, onion, tomato (and juices), garlic and mozzarella in a large bowl. Toss to combine.
  • Drizzle with the olive oil, sprinkle with salt and pepper, and toss again.
  • Spray a baking sheet with cooking spray (or line with parchment). Place two slices of bread on the cookie sheet and top each with half the spinach mixture. Place the second slice of bread on top.
  • Bake for 7-9 minutes or until the spinach is wilted and the bread is toasted. Flip and cook another 3-4 minutes until toasted on the second side.
  • Transfer to a plate and include any of the filling that has fallen out.

Notes

  • Choose a hearty whole wheat bread such as sourdough, rye, or pumpernickel. Soft breads such as white sandwich bread won’t quite stand up to the filling

Nutrition Information

Serving 1sandwich | Calories 235kcal | Carbohydrates 8g | Protein 14g | Fat 17g | Saturated Fat 8g | Cholesterol 44mg | Sodium 389mg | Potassium 382mg | Fiber 2g | Sugar 3g | Vitamin A 3704IU | Vitamin C 19mg | Calcium 325mg | Iron 1mg

Nutrition information is calculated by software based on the ingredients in each recipe. It is an estimate only and is provided for informational purposes. You should consult your healthcare provider or a registered dietitian if precise nutrition calculations are needed for health reasons.

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— This post was originally published on October 9, 2012. It has been updated with new photos and additional information.

Grilled Cheese Florentine on a white serving plate with a napkin, knife, and fork alongside.
5 from 4 votes (3 ratings without comment)

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Recipe Rating




10 Comments

  1. 5 stars
    Excellent flavor! Will make this sandwich often. I put it in my panini press instead of the oven. Pairs wonderfully with cream broccoli soup

    1. Thanks! This one is also good in the air fryer. It’s perfect for the fall with all the delicious soups we have this time of year.

  2. Barbara | Creative Culinary says:

    Wow this looks good. Love every little bit and bite about it!

  3. Just beautiful Lana – love this!

  4. Todd Stone says:

    Lana, we’ve been really trying to eat healthier at our house, more fruits and veggies, less meat. This looks amazing! If I make it for our lunch, and my wife raves about how creative I am, can I just take credit and keep the brownie point all to myself?

    1. Absolutely. I have no idea where you got the idea for that fabulous Grilled Cheese Florentine sandwich :-)

  5. Gio of The Hungry Giant says:

    This looks so good Lana! Do you think this will still work if the spinach mixture is cooked slightly in a pan?

    1. I think it would, Gio. But don’t cook it very much because spinach wilts down to nothing really quickly.

  6. Sommer@ASpicyPerspective says:

    I love a sandwich with a heaping helping of greens, Just gorgeous!