Old Fashioned Turkey Tetrazzini Casserole
Turn those Thanksgiving leftovers into one of the most delicious casseroles ever! Combine chopped roasted turkey and pasta with a creamy, cheesy mushroom sauce to create a hearty Turkey Tetrazzini Casserole your whole family will be excited about!
This Old Fashioned Turkey Tetrazzini Casserole is my standard after-Thanksgiving, use-up-the-turkey casserole. Its ingredients are quite different from the flavors on the Thanksgiving menu and that makes it very welcome.
If you’re wondering just what Turkey Tetrazzini is, it’s an old-fashioned baked pasta casserole. You can make tetrazzini with either turkey or chicken. It’s a perfect recipe for using up leftovers!
While the name may sound like it has Italian roots, the recipe actually doesn’t. It was created in America in the early 1900s. The name comes from a famous Italian soprano, Luisa Tetrazzini.
As with many food origin stories, the exact birthplace of Turkey Tetrazzini is debatable. This one has stories based on both the east and the west coast.
Some say it originated at the Knickerbocker Hotel in New York City while others claim that it came from the Palace Hotel in San Francisco. Which is correct? We’ll probably never know. The only thing that is certain is that it’s one incredibly delicious recipe.
❤ Why We Love This Recipe
- A delicious way to use up leftover turkey
- Classic comfort food that will leave you feeling satisfied
- Kid-friendly pasta dish
🍳 Equipment You’ll Need
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For this recipe, you’ll need a large pot for cooking the spaghetti, a large saute pan, and a 9×13 baking dish.
🥘 Ingredient Notes
Many tetrazzini recipes make use of canned condensed soup and I have absolutely no problem with that. But instead of the standard cream of mushroom soup, for this recipe, I prefer making a creamy cheese sauce with sauteed fresh mushrooms.
- Spaghetti (You can also use angel hair pasta, bow ties, penne, or any other pasta you have on hand. The whole wheat pastas are also good in this casserole.)
- Fresh Mushrooms (Substitute well-drained canned mushrooms if you don’t have fresh.)
- Chicken Broth (If you have homemade chicken broth or leftover turkey broth, it’s even better than canned.)
- Cream Cheese (Having the cream cheese at room temperature will help it melt and blend easier.)
- Parmesan Cheese (Use fresh grated, bagged shredded, or the finely grated boxed type.)
- Pimiento (The pimiento is optional but really does add a lot of flavor and eye appeal.)
- Cooked Turkey or Chicken (This recipe is great for using up turkey leftovers from Thanksgiving or roast chicken leftovers from Sunday dinner. You can also use the meat from a rotisserie chicken in this recipe.)
- Italian Parsley (Dried parsley can be substituted.)
You’ll find detailed measurements for all ingredients in the printable version of the recipe at the bottom of this post.
🔪How to Make Turkey Tetrazzini
Preheat the Oven and Cook the Spaghetti
Preheat the oven to 350 degrees.
Cook the spaghetti according to the package directions. Set aside.
Saute the Vegetables
Coat a large pan with cooking spray and place over medium-high heat. Add butter or margarine. When melted, add mushrooms, onions, and celery. Cook, stirring frequently until tender.
Mix the Flour and Milk into the Vegetables
Whisk together the flour and milk until smooth.
Add the flour-milk mixture along with the chicken broth, salt and pepper to the sautéed vegetables. Bring to a boil, reduce heat and simmer for 5 minutes, stirring occasionally.
Add Remaining Ingredients to Sauce
Remove from the heat and add cream cheese, stirring until melted. Stir in half the Parmesan cheese, garlic powder, pimiento, turkey, spaghetti, and parsley.
Add to Dish and Bake
Spoon the mixture into a shallow baking dish coated with cooking spray. Sprinkle evenly with the remaining Parmesan cheese. Bake for 25-30 minutes or until thoroughly heated.
🍽 How to Serve
I serve this with garlic bread or my cheesy onion and herb bread and a fresh mixed salad with a classic vinaigrette dressing. You could also serve roasted leeks or oven roasted asparagus as a side dish.
🔀 Variations
- For a bit of spice, add 1/4 teaspoon of red pepper flakes to the sauce.
- Some cooks add a cup of frozen green peas in the sauce.
- Vary the pasta and use whatever you have on hand. Angel hair pasta is great in this recipe.
- To make a crunchy topping, toss the remaining Parmesan cheese with a cup of Panko bread crumbs and about two tablespoons of olive oil.
- Make your casserole even richer by substituting half and half for the milk.
🍚 Storage and Freezing
Storing: Leftovers can be stored tightly covered in the refrigerator for 3-4 days.
Freezing: Because of the cream sauce, I can’t recommend freezing. It’s very likely that the sauce would break and the result wouldn’t be great.
Reheating: Reheat in the microwave in one-minute increments, stirring in between to avoid drying out or burning the pasta.
Have you tried this recipe? I’d really appreciate you giving it a star ⭐️⭐️⭐️⭐️⭐️ rating in the recipe card or in the comments section.
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📖 Recipe
Old Fashioned Turkey Tetrazzini Casserole
Ingredients
- 8 ounces spaghetti
- Cooking spray
- 1 tablespoon butter or margarine
- 3 cups sliced fresh mushrooms
- 1 small onion minced
- 2 ribs celery minced
- ½ cup all-purpose flour
- 1 ½ cups milk
- 14.5 ounces canned chicken broth
- 3 ounces cream cheese
- ½ cup grated Parmesan cheese
- ½ teaspoon salt
- ¼ teaspoon pepper
- ½ teaspoon garlic powder
- ¼ cup diced pimiento
- 2 cups chopped cooked turkey or chicken
- ½ cup chopped Italian parsley
Instructions
- Preheat the oven to 350 degrees.
- Cook the spaghetti according to the package directions. Set aside.
- Coat a large pan with cooking spray and place over medium-high heat. Add butter or margarine. When melted, add mushrooms, onion and celery. Cook, stirring frequently until tender.
- Whisk together the flour and milk until smooth.
- Add the flour-milk mixture along with the chicken broth, salt and pepper to the sautéed vegetables. Bring to a boil, reduce heat and simmer for 5 minutes, stirring occasionally.
- Remove from the heat and add cream cheese, stirring until melted. Stir in half the Parmesan cheese, garlic powder, pimiento, turkey, spaghetti and parsley.
- Spoon the mixture into a shallow baking dish coated with cooking spray. Sprinkle evenly with the remaining Parmesan cheese. Bake for 25-30 minutes or until thoroughly heated.
Notes
- Storing: Leftovers can be stored tightly covered in the refrigerator for 3-4 days.
- Freezing: Because of the cream sauce, I can’t recommend freezing. It’s very likely that the sauce would break and the result wouldn’t be great.
- Reheating: Reheat in the microwave in one-minute increments, stirring in between to avoid drying out or burning the pasta.
Nutrition Information
Nutrition information is calculated by software based on the ingredients in each recipe. It is an estimate only and is provided for informational purposes. You should consult your health care provider or a registered dietitian if precise nutrition calculations are needed for health reasons.
— This post was originally published on December 1, 2010. It has been updated with new photos and additional information.
Great dish! I used more Parmesan than called for and forgot the pimentos, but otherwise stuck to the recipe. It didn’t take long to put together and was creamy without being excessively rich. My hubby went back for seconds! Next time I’ll add frozen peas and light panko crust. I settled on this recipe after looking at lots of others and am glad I did!
Thanks so much for letting me know you enjoyed the recipe! I just used the end of our leftover turkey to make one for tonight myself.
Looking forward to making this. I don’t have leftover turkey. I am going to use leftover chicken.sounds delish.
It will be delicious with chicken, Elizabeth!
We used our leftover 20 lb turkey from Easter to make this. Our family has made it for decades with stuffed green olives with pimentos but I left those out but subbed sautéed red bell pepper. We boil the turkey wings and part of the carcus to get all of the meat off the bones and then use the turkey water to boil the spaghetti, making the pasta alot more flavorful. Takes more time doing this but it’s worth it!
I love your idea of cooking the pasta in the turkey broth! I’ll definitely try that myself next time I make this.
I think I have tried every Turkey Tetrazzini recipe there is, and then I came across this one! I about fell over with how it all went together, and how easy it was, but wait…AND how delicious!! Had some friends over and they all loved it! My new standard “go to” recipe! Thank you SO much.
Thank you, Libby. I’m so glad you liked it!
Delicious!! I also used this recipe and substituted chicken.
Yes, I do that sometimes, too. It’s a great way to use leftover rotisserie chicken!
You are so lucky Lana, my mom died before I ever had kids and my grandmother shortly after my first daughter was born. My kids simply never had the childhood I did of family gatherings with generations present. How special!
Turkey Tetrazzini is a given for us after the holidays but I do dress it up a bit. There is BACON! :)
We are lucky, Barb. Very. My grandmother is now 100 and still going strong.
A beautiful family and a beautiful recipe. Thanks so much.
This is the sweetest story of all time. I got a little weepy at the picture of your family together on Thanksgiving. I’m absolutely going to try the recipes. Thank you for sharing your story.
Beautiful family! I’m glad you had a wonderful Thanksgiving. I enjoy all your recipes.
What a wonderful casserole. I am loving this dish.
What a joy to have five (count ’em five) generations together for Thanksgiving dinner, and how I envy you for that. And what a joy your turkey tetrazzini recipe is too! For some reason, I ALWAY associate this dish with the southern part of the US and find myself wondering how and why it became such a dinnertime favorite here. My version, which I make often, is similar to yours except for your superb idea of including cream cheese. That is such a good idea and one I plan to adopt pronto.
I agree, Barbara, that tetrazzini is a decidedly southern casserole but have no idea why that is so. Unless it started with homemade noodles or thin dumplings at the beginning and gradually evolved to the more easily prepared dried pasta. Just a guess.
Lana, I love the picture of your family — how amazing! What a great way to use up turkey! I love casseroles!
I love turkey tetrazzini. I haven’t had it in a very long time. Yours looks great!
now Lana, that is something to be proud of, having all in one place, and what a beautiful picture… nothing better than family photos and nothing better that being able to spend time with the ones you love… hey, this recipe is out of sight, Momma taught me to do a chicken version many years ago and is it very similar…. reminds me to git out my cookbook and start cooking family favorites…
Those are my Peeps!
Miss P
Sho’ nuf.
Beautiful picture, beautiful family. 5 generations is really something. You must have had a terrific holiday!
Your recipe looks delish as always ;)
It was a fine day, Teri. Wouldn’t take anything for having family all together.
I adore the picture of your multigenerational family. What a wonderful tribute to them! Our turkey is gone, but I’ll remember your recipe for next time. It sounds delicious and homey.
What a great photo, I’m so happy for you, I know you’ll treasure it! Your turkey tet looks mighty good too:@)
Thanks! It’s a pretty tasty recipe.
Wow! What a beautiful family! And FIVE generations?…that’s impressive! We would brag about 4 generations until we lost grandmother at 93 1/2 a few months ago! You come from a dandy stock lovely lady!
Thank you, Wendy. We are so very fortunate to have each other!